Multidrug-resistant (MDR) Gram-negative bacteria information leaflets
نویسندگان
چکیده
منابع مشابه
A traceless reversible polymeric colistin prodrug to combat multidrug-resistant (MDR) gram-negative bacteria.
Colistin methanesulfonate (CMS) is the only prodrug of colistin available for clinical use for the treatment of infections caused by multidrug-resistant (MDR) Gram-negative bacteria. Owing to its slow and variable release, an alternative is urgently required to improve effectiveness. Herein we describe a PEGylated colistin prodrug whereby the PEG is attached via a cleavable linker (col-aaPEG) i...
متن کاملCombination antibiotic therapy for multidrug-resistant Gram-negative bacteria
Combination antibiotic therapy for Gram-negative sepsis is controversial. The present review provides a brief summary of the existing knowledge on combination therapy for severe infections with multidrug-resistant Pseudomonas spp., Acinetobacter spp., and Enterobacteriaceae. Empirical combination antibiotic therapy is recommended for severe sepsis and septic shock to reduce mortality related to...
متن کاملTrends of 9,416 multidrug-resistant Gram-negative bacteria.
OBJECTIVE a resistance of hospital-acquired bacteria to multiple antibiotics is a major concern worldwide. The objective of this study was to investigate multidrugresistant (MDR) bacteria, clinical specimens, origin of specimen and trends, and correlate these with bacterial sensitivity and consumption of antimicrobials. METHODS 9,416 bacteria of nosocomial origin were evaluated in a tertiary ...
متن کاملThe effect of ethanolic and aqueous extracts of Berberies vulgaris on multidrug- resistant gram-negative pathogenic bacteria
Background and Aim: In recent years, due to the indiscriminate and irrational use of synthetic drugs, the resistance of pathogenic microorganisms has increased; therefore, new compounds are vitally needed. The purpose of this study was to investigate the effect of ethanolic and aqueous extracts of Berberis vulgaris on Escherichia coli, Klebsiella pneumoniae, Proteu...
متن کاملMultidrug efflux pumps of gram-negative bacteria.
Gram-negative bacteria tend to be more resistant to lipophilic and amphiphilic inhibitors than gram-positive bacteria. Such inhibitors include dyes, detergents, free fatty acids, antibiotics, and other chemotherapeutic agents. This property is used in the selective enrichment of gram-negative bacteria, especially of members of the family Enterobacteriaceae, for example with MacConkey agar (cont...
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ژورنال
عنوان ژورنال: Journal of Hospital Infection
سال: 2016
ISSN: 0195-6701
DOI: 10.1016/j.jhin.2015.08.014